Crews Research Group

Evaluating Nitrogen-Containing Biosynthetic Products Produced by Saltwater Culturing of Several California Littoral Zone Gram-Negative Bacteria. Lorig-Roach N, Still PC, Coppage D, Compton JE, Crews MS, Navarro G, Tenney K, Crews P. J. Nat. Prod. (2017) doi: 10.1021/acs.jnatprod.7b00302 Link

Another Look at Pyrroloiminoquinone Alkaloids—Perspectives on Their Therapeutic Potential from Known Structures and Semisynthetic Analogues Lin S, McCauley E, Lorig-Roach N, Tenney K, Naphen C, Yang A-M, Johnson T, Hernadez T, Rattan R, Valeriote F, Crews P. Mar. Drugs (2017) doi: 10.3390/md15040098 Link

Identification of the First Marine-Derived Opioid Receptor “Balanced” Agonist with a Signaling Profile That Resembles the Endorphins. Johnson TA, Milan-Lobo L, Che T, Ferwerda M, Lambu E, McIntosh NL, Li F, He L, Lorig-Roach N, Crews P, Whistler JL. ACS Chem. Neurosci. (2017) doi: 10.1021/acschemneuro.6b00167 Link

The Bengamides: A Mini-Review of Natural Sources, Analogues, Biological Properties, Biosynthetic Origins, and Future Prospects
White KN, Tenney K & Crews, P. J. Nat. Prod. (2017) doi: 10.1021/acs.jnatprod.6b00970 Link

Biosynthetic products from a nearshore-derived gram-negative bacterium enable reassessment of the kailuin depsipeptides.
Theodore CM, Lorig-Roach N, Still PC, Johnson TA, Draškovic M, Schwochert JA, Naphen CN, Crews MS, Barker SA, Valeriote FA, Lokey RS, Crews P. J. Nat. Prod. (2015) doi: 10.1021/np500840n. Link

A New 3-Alkylpyridine Alkaloid from the Marine Sponge Haliclona Sp. and Its Cytotoxic Activity.
Zhang, H.; Loveridge, S. T.; Tenney, K.; Crews, P. Natural Product Research (2015) doi: 10.1080/14786419.2015.1054826 Link

Scrutinizing the Scaffolds of Marine Biosynthetics from Different Source Organisms: Gram-Negative Cultured Bacterial Products Enter Center Stage.
Still, P. C.; Johnson, T. A.; Theodore, C. M.; Loveridge, S. T.; Crews, P. J. Nat. Prod. 77, (2014) 690-702 doi: 10.1021/np500041x Link

Thelepamide: An Unprecedented Ketide-Amino Acid from Thelepus crispus, a Marine Annelid Worm.
Rodríguez, J.; Nieto, R. M.; Blanco, M.; Valeriote, F. A.; Jiménez, C.; Crews, P. Organic Letters 16 (2014) 464-467 doi: 10.1021/ol403350e Link

Study of Marine Natural Products Including Resorcyclic Acid Lactones from Humicola fuscoatra That Reactivate Latent HIV-1 Expression in an in Vitro Model of Central Memory CD4+ T Cells.
Mejia, E. J.; Loveridge, S. T.; Stepan, G.; Tsai, A.; Jones, G. S.; Barnes, T.; White, K. N.; Draškovic, M.; Tenney, K.; Tsiang, M.; et al. J. Nat. Prod. 77 (2014)618-624 doi: 10.1021/np400889x Link

Chemically diverse microtubule stabilizing agents initiate distinct mitotic defects and dysregulated expression of key mitotic kinases.
Rohena, C. C.; Peng, J.; Johnson, T. A.; Crews, P.; Mooberry, S. L. Biochem. Pharmacol. 85 (2013) 1104-1114 doi: 10.1016/j.bcp.2013.01.030. Link

Structures and Cytotoxic Evaluation of New and Known Acyclic Ene-Ynes from an American Samoa Petrosia sp. Sponge.
Mejia, E. J.; Magranet, L. B.; De Voogd, N. J.; TenDyke, K.; Qiu, D.; Shen, Y. Y.; Zhou, Z.; Crews, P. J. Nat. Prod. 76 (2013) doi: 10.1021/np3008446 Link

Discovery and development of anticancer agents from marine sponges: perspectives based on a chemistry-experimental therapeutics collaborative program.
Valeriote, F. A.; Tenney, K.; Media, J.; Pietraszkiewicz, H.; Edelstein, M.; Johnson, T. A.; Amagata, T.; Crews, P. Journal of Experimental Therapeutics & Oncology 10 (2012) 119-134 Link

Development and Validation of a Simple Method for the Detection of Fascaplysin in Plasma.
Swartz KH, Valeriote FA, Media J, Johnson TA, Tenney K, et al. J Anal Bioanal Techniques 3 (2012) doi: 10.4172/2155-9872.1000150 Link

Natural product libraries to accelerate the high-throughput discovery of therapeutic leads.
Johnson TA, Sohn J, Inman WD, Samarkand AE, Loveridge ST, Vervoort HC, Tenney K, Liu J, Ang KKH, Ratnam J, Bray WM, Gassner NC, Shen YY, Lokey RS, McKerrow JH, Boundy-Mills K, Nukanto A, Kanti A, Julistiono H, Kardono LBS, Bjeldanes LF, Crews P. J. Nat. Prod. 74, (2011) 2545-2555. PMID: 22129061. Link